Last edited by Tojabei
Tuesday, July 14, 2020 | History

4 edition of Quantitative drug design found in the catalog.

Quantitative drug design

Yvonne Connolly Martin

Quantitative drug design

a critical introduction

by Yvonne Connolly Martin

  • 145 Want to read
  • 29 Currently reading

Published by M. Dekker in New York .
Written in English

    Subjects:
  • Drugs -- Structure-activity relationships.,
  • Drugs -- Structure-activity relationships -- Mathematical models.

  • Edition Notes

    Includes bibliographies and indexes.

    StatementYvonne Connolly Martin.
    SeriesMedicinal research ;, v. 8
    Classifications
    LC ClassificationsQP906.S75 M37
    The Physical Object
    Paginationx, 425 p. :
    Number of Pages425
    ID Numbers
    Open LibraryOL4556531M
    ISBN 100824765745
    LC Control Number77026709

      Quantitative pharmacology is a multidisciplinary approach in drug development that emphasizes the integration of the relationships between diseases, drug characteristics, and individual variability across studies and development phases for rational and scientifically based decision making (19,20). It is a move away from the traditional study Cited by: In Silico Drug Design: Repurposing Techniques and Methodologies explores the application of computational tools that can be utilized for this approach. The book covers theoretical background and methodologies of chem-bioinformatic techniques and network modeling and discusses the various applied strategies to systematically retrieve, integrate and analyze .

    Quantitative structure–activity relationships (QSAR) are mathematical relationships linking chemical structure and pharmacological activity in a quantitative manner for a series of s which can be used in QSAR include various regression and @[email protected] techniques. QSAR is often taken to be equivalent to @[email protected] or multivariate statistical .   QSAR: quantitative structure-activity relationships in drug design: proceedings of the 7th European Symposium on QSAR, held in Interlaken, Switzerland, September by European Symposium on Quantitative Structure-Activity Relationships (7th: Interlaken, Switzerland);Fauchère, J. L. (Jean-Luc)Pages:

    Find many great new & used options and get the best deals for Drug Discovery: Drug Design Strategies: Quantitative Approaches 13 (, Hardcover) at the best online prices at eBay! Free shipping for many products! Read "Quantitative drug design: A critical introduction. Medicinal research series vol. 8. By Yvonne Connolly Martin. Dekker, Madison Ave., New York, NY pp. 15 × 23 cm. Price $, Journal of Pharmaceutical Sciences" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your .


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Quantitative drug design by Yvonne Connolly Martin Download PDF EPUB FB2

Based on the author’s four decades of experience in all areas of ligand-based computer-assisted drug design, this invaluable book describes how to transform ligand structure-activity relationships into models that predict the potency or activity/inactivity of new molecules.

It will help you avoid traps when dealing with quantitative drug by: 3. Based on the author’s four decades of experience in all areas of ligand-based computer-assisted drug design, this invaluable book describes how to transform ligand structure-activity relationships into models that predict the potency or activity/inactivity of new molecules.

It will help you avoid traps when dealing with quantitative drug design. Quantitative Drug Design 2nd Edition PDF – A Critical Introduction Quantitative Drug Design 2nd Edition PDF Free Download, Quantitative Drug Design 2nd Edition PDF, Quantitative Drug Design 2nd Edition Ebook Content Since the publication of the first edition, the field has changed dramatically.

Scientists can now explicitly consider 3D features in quantitative structure-activity. Quantitative Drug Design: A Critical Introduction, Second Edition - Kindle edition by Yvonne C. Martin. Download it once and read it on your Kindle device, PC, phones or tablets.

Use features like bookmarks, note taking and highlighting while reading Quantitative Drug Design: A Critical Introduction, Second Edition. Chemists, pharmacologists, biochemists, and people involved in drug design and manufacture will find the book invaluable.

Show less Drug Design, Volume VIII covers a critical review and new extensions of quantitative methods in drug design, the design of particular types of agents, such as synthetic sweeteners, and selective ion binding compounds. This book brings together drug design practitioners, all leaders in their field, who are actively advancing the field of quantitative methods to guide drug discovery, from structure-based design to empirical statistical models - from rule-based approaches to toxicology to the fields of bioinformatics and systems biology.

The aim of the book is to show how various facets of the. Get this from a library. Quantitative drug design: a critical introduction. [Yvonne Connolly Martin] -- "Incorporating the novel developments that have occurred in this field since the publication of the first edition, Quantitative Drug Design: A Critical Introduction, Second Edition shows scientists.

Book Description. State-of-the-Art Methods for Drug Safety Assessment. Responding to the increased scrutiny of drug safety in recent years, Quantitative Evaluation of Safety in Drug Development: Design, Analysis and Reporting explains design, monitoring, analysis, and reporting issues for both clinical trials and observational studies in biopharmaceutical product development.

Content. Responding to the increased scrutiny of drug safety in recent years, Quantitative Evaluation of Safety in Drug Development: Design, Analysis and Reporting explains design, monitoring, analysis, and reporting issues for both clinical trials and observational studies in biopharmaceutical product development.

Modern pharmaceutical industries have faced significant challenges to deliver safe and effective medicines because of significant toxicity and severe side effects of discovered drugs. On the other hand, recent developments and advances in system-based pharmacology aim to address these challenges.

In this chapter, we provide an overview of quantitative methods for system-based Author: Yu-Chen Lo, Ren Gui, Hiroshi Honda, Jorge Z.

Torres. Classical quantitative structure–activity relationship (QSAR) has provided the foundation of modern QSAR concepts. It includes the de novo model (mathematical approach) of Free–Wilson, as well as its modified version as suggested by Fujita and Ban, and the linear free-energy-related (LFER) approach of Hansch, which has been very successful in its application in QSAR studies.

design, and biostructure-based drug design. The authors also discuss drug-like properties and decision making in medicinal chemistry, chemical biology, natural products in drug discovery, and in vivo imaging in drug discovery.

The middle six chapters provide an overview of peptide and protein drug design, prodrugs in drug design and development. This book offers a high-level treatise of evidence-based decisions in drug development. Because of the inseparable relationship between designs and decisions, a good portion of this book is devoted to the design of clinical trials.

The book begins with. This book brings together drug design practitioners, all leaders in their field, who are actively advancing the field of quantitative methods to guide drug discovery, from structure-based design to empirical statistical models - from rule-based approaches to toxicology to the fields of bioinformatics and systems biology.

Thus, the book should be valuable for medicinal, agricultural and theoretical chemists, biochemists and biologists, as well as for other scientists interested in drug design. Its content, starting at a very elementary level and proceeding to the latest methodological results, the strengths and limitations of 3D QSAR approaches, makes the book.

Unique work on structure-based drug design, covering multiple aspects of drug discovery and development. Fully colored, many images, computer animations of 3D structures (these only in electronic form). Makes the spatial aspects of interacting molecules clear to the reader, covers multiple applications and methods in drug design.

The Assay Guidance Manual (AGM) is an eBook of best practices for the design, development, and implementation of robust assays for early drug ted by pharmaceutical company scientists, the manual provides guidance for designing a “testing funnel” of assays to identify genuine hits using high‐throughput screening (HTS) and advancing them Cited by: 7.

Drug design, often referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target.

The drug is most commonly an organic small molecule that activates or inhibits the function of a biomolecule such as a protein, which in turn results in a therapeutic benefit to the patient.

This book offers a high-level treatise of evidence-based decisions in drug development. Because of the inseparable relationship between designs and decisions, a good portion of this book is devoted to the design of clinical trials. The book begins with an overview of product development and regulatory approval pathways.

The book’s three sections focus on study design, safety monitoring, and data evaluation/analysis. The book addresses key challenges across regulatory agencies, industry, and academia.

It discusses quantitative approaches to safety evaluation and risk management in drug development, covering Bayesian methods, effective safety graphics, and.

The book provides a summary of the current state-of-the-art in quantitative approaches to drug design, and future opportunities, but it also provides inspiration to drug design practitioners to apply careful design, to make best use of the quantitative methods that are available, while continuing to improve : Qualitative Data Analysis in Drug Research.

Research design: Qualitative, quantitative, and mixed methods approaches. This book focuses on .Quantitative drug design. G. Redl, R. D. Cramer tert. and C. E. Berkoff Abstract. The first page of this article is displayed as the abstract.

About. Cited by Authors contributing to RSC publications (journal articles, books or book chapters) do not need to formally request permission to reproduce material contained in this article.